Author(s):

Zamin Ahmad, Kusum Singh, Akhtar Rasool, Mir Imran and Faisal Yousuf

Abstract: Background and purpose of study: Bougainvillea spectabilis and Catharanthus roseus extracts are part of various herbal formulations for the treatment of diabetes. The present study aims to determine the biochemical alterations due to Co-administration of Bougainvillea spectabilis and Catharanthus roseus leaf extracts on female diabetic albino rats. Materials and Methods: Bougainvillea spectabilis and Catharanthus roseus leaves extracted with methanol and administered to both normal and alloxan induced diabetic rats. The acid phosphatase and alkaline phosphates levels were measured at 7, 14 and 21 days at a dose level of 300 mg/kg b.wt. Results and Discussion: In the present study, effect of Methanolic extract of combination of Bougainvillea spectabilis and Catharanthus roseus in various organs of diabetic albino rats significantly decreased the acid phosphatse as well as alkaline phosphatase content at 300mg/kg b.wt for intervals of 7, 14 and 21 days. It may be due to the presence of certain phytoconstituents of plants such as flavonoids, Saponins etc.

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