Poonam Pardhi, Mrunali Patle, Vishakha Oimbe and Shubhangi Raut

The study aimed to extract and evaluate Indian Finger Millets starch and compare its performance as disintegrant with commercially available Maize starch in tablet formulations. Indian Finger Millets starch was extracted using a wet milling method, and its physicochemical properties were characterized. Paracetamol tablets were prepared using Indian Finger Millets starch and Maize starch as disintegrants in different concentrations. The tablets were evaluated for various parameters. The extracted Indian Finger Millets starch exhibited good powder flow properties with a Carr's Index of 15.6% and an angle of repose of 27.4°. The post-compression evaluation, optimized Indian Finger Millets starch tablets (MF5) demonstrated a hardness of 6.0±0.2 kp, disintegration time of 6.0±0.30 min, and 99% drug release at 60 minutes. The optimized Maize starch tablets (PF3) showed a hardness of 6.5±0.4 kp, disintegration time of 6.5±0.20 min, and 91% drug release at 60 minutes. 

DOI: 10.22271/phyto.2024.v13.i3e.14980

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