Ama Dénis-Marcel Assi, Adja Rodrigue Beli, Kacou Jules Marius Djetouan, Jeanne Akoua Kanga, Apy Simone Abe and Kouao Augustin Amonkan

Petroselinum sativum (Apiaceae) plant is used in traditional medicine practice for the management of many pathologies including renal and liver diseases. Therefore, the current study aims to investigate the hepatoprotective effect of Petroselinum sativum (Apiaceae) against acetaminophen hepatotoxicity in rats. To achieve this aim, thirty adult male albino rats were divided into equal five groups as following, Group I, negative control received 0.9% NaCl orally (Control + NaCl); Groups II, Positive control, received acetaminophen solution at 200 mg/kg bw (Acetam. 200), Groups III, IV, and V received acetaminophen solution at 200 mg/kg bw and vitamin E (250 mg/kg bw), Petroselinum sativum strand ethanolic extract at 200 and 400 mg/kg bw respectively. At the end of experiment (after 7 days), blood samples were collected for biochemical and hematologic analysis.

Renal toxicity and oxidative stress were observed in untreated paracetamol-intoxicated rats asResult shown the body-weight gain (p<0.0001) was observed at the 200 mg/kg bw dose of EEBPs. Water consumption (p<0.001) and food consumption (p<0.0001) were improved at 200 and 400 mg/kg bw. Extract of Petroselinum sativum strand resulted in a significant improvement in blood ionograms and renal biomarkers compared with group II, including a significant (p<0.05; p<0.001; p<0.0001)) in creatinine, urea, and total protein. In the liver, there was a significant reduction in hepatic biomarkers and an improvement in hematological parameters.

DOI: 10.22271/phyto.2024.v13.i1e.14856

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