Andrew Kwaji, Saminu Yunana, Samaila Abubakar and Atiko Rejoice

Chrozophora senegalensis is a medicinal plant with widespread use in Northern Nigeria by the local populace for treatment of ailments and diseases such as diarrhea, malaria and dysentery. The study evaluated the Cytotoxicity of C. senegalensis crude methanol extract using brine shrimp lethality test. The plant sample was air dried at room temperature, pulverized to powder and subjected to maceration with methanol. The marc was removed by double filtration using cotton wool and Whatmann No.1 filter paper. The filtrate obtained was concentrated on a rotary evaporator at 45 °C. The crude extract was partitioned between hexane and ethyl acetate and subjected to Cytotoxicity assay using brine shrimp lethality test. The study revealed that the C. senegalensis extracts are highly cytotoxic to the brine shrimp larvae with LC₅₀ of 4.68 µg/mL and 0.76 µg/mL for the hexane and ethyl acetate fractions respectively. The results suggest that the ethylacetate fraction is more cytotoxic than the hexane fraction. However, the study had shown that C. senegalensis contains bioactive principles which could be useful as antitumor agent and partly justify its use in traditional medicine practice.

DOI: 10.22271/phyto.2023.v12.i5b.14721

Pages: 132-134  |  467 Views  227 Downloads