Mudassir Alam, Kashif Abbas, Mohd Ali, Shakir Kamal and Shipra Bhagia

Hepatitis B virus (HBV) is an essential human disease and hepatotropic virus. An estimated 296 million chronically infected persons in the globe, and many of them may acquire severe liver disorders such as hepatitis, cirrhosis, hepatocellular cancer (HCC) and hepatomegaly. Trapa natans L. thrives in lakes and rivers with sunny locations and slightly acidic water. According to the literature, water chestnut ae rich in crucial minerals, proteins, lipids, carbohydrates, vitamins, dietary fibres, polyphenols such as phenolic acids and flavonoids, and hydrolysable tannins. Trapa natans are rich in phenols and flavonoids. Several investigations have shown that Trapa natans leaf extract has potential pharmacological action, including hepatoprotective and anti-inflammatory properties. The study aims at In silico and ADME/T analysis of active compounds present in Trapa natans leaf extract against NTCP to evaluate and visualize protein-ligand interaction.

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