Author(s):

Athira Mohan, Dr. Vinay Jain and Megha Jain

Abstract: Cyclophosphamide (CYP) is an alkylating anti-tumor drug. CYP has many adverse effects, partly due to oxidative stress induction in various tissues. Rutin is one of the natural flavonoids with strong antioxidant properties. The aim of this study was to determine the nephrprotective effect of rutin against toxic effect of cyclophosphamide. The study was performed on swiss albino mice. Thirty male mice were divided into six group. The first group received normal saline for 14 days. The second group received only cyclophosphamide drug 25 mg/kg., i.p. on 0 to 14 days. The third group received amifostine drug prior 1hour before the administration along with cyclophosphamide (25mg/kg) respevtively for 14 days. The group fourth and five received 40mg/kg and 80mg/kg of rutin after the administration of cyclophosphamide (25mg/kg) respectively for 14 days. Cyclophosphamide administration significantly (P<0.05) decreased the levels of antioxidant markers such as superoxide dismutase (SOD), catalase (CAT) and increased lipid peroxidation (LPO). Cyclophosphamide elevated the levels of hematological variables like RBCs, WBCs, Hb and biomarker enzymes like Albumin, Creatinine and Total protein. Treatment with Rutin significantly (P<0.05) reversed the status serum biomarkers, hematological variables and antioxidant markers in cyclophosphamide induced nephrotoxicity. The results concluded that Rutin has shown nephoprotective effect against toxicity induced by cyclophosphamide in mice.

DOI: 10.22271/phyto.2020.v9.i5y.12596

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