Antioxidant and anticancer activities of pericarp of Garcinia mangostana L.

Geetha S; K Saraswathi; Gayathri Devi Chakrapani; Sivaraj C; Dhivya M; Chittibabu CV

Antioxidant and anticancer activities of pericarp of Garcinia mangostana L.

Author(s):

Geetha S, K Saraswathi, Gayathri Devi Chakrapani, Sivaraj C, Dhivya M and Chittibabu CV

Abstract:

Natural products play an important role in protection against reactive oxygen species to maintain a state of well-being health, including the prevention of cancer progression. Garcinia mangostana has a rich history dates back in its antioxidant activity and cytotoxicity of xanthones on some cancer cells. Food sources have variety of phytonutrients, as antioxidants have health-protecting qualities required for healthy survival. The phytocompounds in herbs to inhibit the rate of cancer growth and they are harmless as well as safe to use. Garcinia mangostana fruits are roughly 4-8 cm in size with a thick, brittle, deep purple spherical outer pericarp. The edible snow white endocarp consists of 4 to 8-segmented wedge-shaped arils. G. mangostana fruit and its pericarp possess potential medicinal properties in the ancient treatment strategies. The bioactive substances present in it are utilized in the Ayurvedic treatment of chronic infections and other ailments. People in Southeast Asia have used dried mangosteen pericarp as an antiseptic, an analgesic, an anti-inflammatory, anti-parasitic, antipyretic and as a treatment for skin rashes since ancient times. Although the fruit pulp has several utilisations, the present study was to evaluate the antioxidant activity of methanol extract of Mangosteen pericarp and its anticancer activity against breast cancer cells (MCF7).

The antioxidant activity was carried out by DPPH radical and ABTS^●+radical cation scavenging assay methods as well as phosphomolybdenum reduction and Fe³⁺ reducing power assay methods. Anticancer activity was done in MCF-7 cancer cell line by MTT assay method. The maximum DPPH radical scavenging activity was 78.58±0.89% at 300 µg/mL concentration The results showed that the methanol extract of pericarp of G. mangostana, effectively inhibit free radicals and the antioxidant activity increases with increasing concentration of the extract. The maximum MCF7 cell death by G. mangostana pericarp extract was 67.05±1.28% at 500 µg/mL concentration and the cell death increases with increasing concentration of the extract.

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Journal of Pharmacognosy and Phytochemistry

How to cite this article:

Geetha S, K Saraswathi, Gayathri Devi Chakrapani, Sivaraj C, Dhivya M and Chittibabu CV. Antioxidant and anticancer activities of pericarp of Garcinia mangostana L.. J Pharmacogn Phytochem 2020;9(4):1805-1809.

Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

Vol. 9, Issue 4 (2020)

Antioxidant and anticancer activities of pericarp of Garcinia mangostana L.

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