Bio fortification is one solution among many interventions that are needed to solve the complex problem of micronutrient malnutrition. There are several options for Bio fortification, among which genetic and agronomic Bio fortification are mostly used. Agronomic Bio fortification mainly refers to adequate fertilization using an appropriate method and time of application. It gives immediate results and in, general, goes well along with an increase in yield. In aerobic rice, application of ZnSO₄ at 25 kg/ha as basal + foliar spray at 0.5% at three stages reveals significantly highest Zn content in grain (35.09 mg/kg) (Barua and Saikia, 2018). Conventional breeding is the most accepted method of Bio fortification. It offers a sustainable, cost-effective alternative to transgenic and agronomic-based strategies. QPM is the best example for conventional breeding. QPM contain higher lysine and tryptophan than traditional varieties (Vasal et al., 1980). Bio fortification of important crop plants through biotechnological applications is a cost-effective and sustainable solution for alleviating Vitamin A Deficiency. Genetic engineering is the obvious alternative to enhance the β carotene levels in crop plants like Golden rice. Awareness of dietary diversity must be followed up to alleviate micronutrient malnutrition. As people of under developed nations cannot afford to supplemented and diversified foods, Research and development of nutrient enriched bio fortified crops should be carried out to address malnutrition problem. The Bio fortification programme along with conventional breeding and Agronomic aspect will become the first choice of the researchers for crop improvement in future.