Author(s):

Pawar Pooja, Hajare SW, RS Ingole, MV Ingawale, Payal Rathod, Sapna Jamgade and Prajakta Kuralkar

Abstract: The present investigation was carried out on “Effect of acetamiprid on malathion induced clinical signs, general performance and hematological alterations in Wistar rats”. The study was conducted on 36 Wistar rats which were divided into five groups viz., group I (control), group II (malathion 30 mg/kg BW), group III (acetamiprid 27 mg/kg BW), group IV (malathion 30 mg/kg + acetamiprid 13.5 mg/kg) and group V (malathion 30 mg/kg + acetamiprid 27 mg/kg BW) received treatment for 28 consecutive days. In results of the study, group III and V rats showed depression, pasty faeces, reduced feed consumption and mild salivation. From first week onwards significantly (P<0.05) lowered weekly body weights were observed in group II, III, IV and V rats as compared to control till the experimental period of 4 weeks. Hematological findings of group II, III and V revealed significant (P<0.05) decrease in Hb, PCV, TEC, lymphocyte along with significant increase in TLC and neutrophil count as compared with control. In conclusion, acetamiprid alone and its high dose combination with malathion produces deleterious effect on haematological parameters. However, acetamiprid at low dose combination with malathion, antagonizes toxic effect of malathion on hematological parameters.

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