Author(s):

Moctar Chaibou, Habibou Hama Hamadou, Abdoul Nasser Moussa Bamba, Zakari Chaibou Ousmane, Moussa Idrissa, Arzika Tanimoune and Khalid Ikhiri

Abstract: The search for alternatives to anthelminthics drugs becomes essential in order to control gastrointestinal worms because of resistance developed by helminths with regard to synthetic anthelmintics available and the high cost of these. The aim of this work is to evaluate the vermicidal properties in vitro of ethanolic extracts of Bauhinia rufrescens (Fabaceae) and Chrozophora brocchiana (Euphorbiaceae) two plants used as antiparasitic in Niger. Adult worms (A. galli) of approximately equal sizes are used. Different concentrations (2g / L, 5g / L and 10g / L) were prepared and tested. The phytochemical screening revealed the presence of tannins, flavonoids, steroids and terpenoids in both. There were not alkaloid and saponins in all extracts. All extracts showed vermicidal activity with 100% inhibition of motility before 24 hours. Compared with the negative control (NaCl 0.9%) which gives 100% inhibition of motility, after 72 hours, these extracts are significantly effective (p<0.05). These results confirm their traditional uses as dewormer. Studies on other types of worms will be conducted. Also in vivo tests are possible. Further studies will be done in order to elucidate active compounds structure.

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