Author(s):

Deutchoua Eric Martial, Mang Yannick Dimitry, Sokeng Dongmo Selestin and Njintang Yanou Nicolas

Abstract: Clerodendron thomsoniae leaves are traditionally used to treat obesity. The effect of Aqueous extract doses (312.5 mg/kg, 625 mg/kg, 1250 mg/kg) on the lipid-lowering and antioxidant potential of Clerodendron thomsoniae Linn (C. thomsoniae) leaves was assessed. The rats rendered hyperlipidemic after five weeks of feeding with high fat diet were administered aqueous extract of C. thomsoniae leaves by oral gavage for four weeks. The total phenolics and the DPPH scavenging activity of the extracts, the lipid profile and the antioxidant parameters of rat plasma administered C. thomsoniae extracts were measured. Results revealed that the level of phenolic compounds in the 3 doses (3.1-12.5 mg/L) of extract administered varied from 0.45 (g/100 g D.M.)) to 1.81(g/100 g D.M.). The equivalent variation of DPPH scavenging activities was 78.3% to 97.1%. Biological analysis revealed a decrement in plasma total cholesterol, triglycerides, LDL cholesterol and VLDL cholesterol along with an increase in HDL cholesterol in rats administered C. thomsoniae extract as compared to negative control rat group. A dose dependent variation was observed with the highest dose 1250 mg/kg exhibiting the highest percent change 33%, 51%, 37%, 43% and 62%, respectively. Similarly, significant dose-dependent reductions in blood glucose and abdominal fat contents were observed. In addition, the extract induced in a dose dependent manner significant increase in the catalase and superoxide dismutase activities in the plasma, and a decrease in malondialdehyde concentration. Lipid-lowering property of the C. thomsoniae extract in chronic hyperlipidemic rats validates its use traditionally as a part of folklore medicine in Ngaoundere-Cameroon, though there is no scientific evaluation to date to our knowledge

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