Author(s):

Prabhat Gangwar, PC Shukla, Amita Tiwari, G Das, Shivangi Sharma and Shivangi Udainiya

Abstract: The present study was conducted to know the haemato-biochemical alternations and to compare the therapeutic efficacy of different anti-trypanosomal drugs in buffaloes. Total of 118 buffaloes of either sex, age group and parity were screened for trypanosomosis. The haematological alternations in the infected buffaloes showed decreased pre treatment values of Hb, PCV, TEC which got increased on 3rd and 7^th day post treatment in all the groups. But Erythrocytic indices remained altered with no significance. The mean value of TLC (10³/µl) noted markedly decreased on post treatment in all the groups.The biochemical studies revealed no alternation in the mean values of Total protein in all the treated groups on post treatment than the pre treatment mean values 1^st day. On the contrary, marked increased mean values of glucose have been obtained on 3^rd and 7^th days post treatment in the T3 group. The AST values found under study were reported to be significantly reduced in all the groups post treatment, but maximum reduction was obtained in T3 groups on day 3^rd day 7^th. It was concluded that out of the drugs used isometamidium chloride was found to be most effective as evident by the maximum clinical recovery.

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