Author(s):

Huiam Salah Eldeen Izz Eldeen Abd Alaziz and Mona Abdelmoneim Mohamed Abdelmageed

Abstract: Adansonia digitate Linn (Malvaceae) is a native plant to the west Sudan, locally named Tabaldy. Adansonia digitate seeds are believed to have nutritional and medicinal benefits in Sudan. The aims of this study are to screening the phytochemicals of Adansonia digitate L seeds ethanol extract and to test its antimicrobial activity, antioxidant and cytotoxicity. The phytochemical screening reveals the presence of glycosides, saponins, steroids and flavonoids, protein, but alkaloids, tannins and resins are not detected. The antioxidant test of baobab seeds ethanol extract by using DPPH scavenging test revealed a moderate activity (53.04±0.067) with IC₅₀ value 0.092± 0.006. The cytotoxicity was tested using cancer cell line : lung cancer cell(A549), breast cancer cell (MCF7), hepatic cancer cell (HEPG2) and normal cell line melanocytes cell (HFB4),and fibrinocytes cell( BHK). The cytotoxicity result of the seed aqueous ethanol extract was exhibited a cytotoxic effect against the normal cell tested ( HFB4),(BHK) with IC₅₀ 11.6, and 24.5 µg/ml respectively and no effect on cancer cell tested except (MCF7) cell with IC₅₀ 11.5 µg/ml. the antibacterial activity tested against three standard bacterial strains Staphylococcus aureus, Eschericia coli, and Bacillus subtilis using cup diffusion method.The antibacterial activity result revealed a moderate activity against Eschericia coli (17mm), and high activity against both Staphylococcus aureus, and Bacillus subtilis with inhibition zone diameter 28mm, and 21mm respectively. this study dose not support the used of seeds powder as nutrition due to cytotoxic effect.

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