Author(s):

P Anusha and S Rajkumar Immanuel

Abstract: Cancer remains one of the leading causes of morbidity and mortality globally and is responsible for one in eight deaths worldwide. Amongst the non-communicable diseases, cancer is the second leading cause of death, after cardiovascular disease Chemotherapy is routinely used for cancer treatment. Since cancer cells lose many of the regulatory functions present in normal cells, they continue to divide when normal cells do not. This feature makes cancer cells susceptible to chemotherapeutic drugs. There are several factors for the continued popularity of traditional drugs and one is their ready availability as compared to the modern medicines besides the adverse effects of synthetic drugs. The aim of the present study was to evaluate the anticancer activity and GC-MS analysis of methanol extract of leaves of H. auriculata. MTT assay method was carried out for anticancer activity on A549 (lung) and HepG2 (liver) cancer cell lines. The maximum cell death of lung cancer cells was 70.54±0.004% and liver cancer cells was 72.37±0.002% at 160 µg/mL concentration of methanol leaves extract of H. auriculata. Antioxidant compound 5-Hydroxy-7-methoxy-2-phenyl-4H-1-Benzopyran-4-one was eluted by GC-MS, which neutralize free radicals, which causes oxidative stress to cells, leads to cancer.

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