Author(s):

Bhalchim S, Ballurkar BV, Ranvir GD, Pawar AR and Jadhav ND

Abstract: A large population of India is using herbal products for their healing, preventive, curative and many therapeutic properties along with immunomodulatory property. Clinical uses of immunostimulants are in treatments of diseases like immune compromise disorders such as AIDS, chronic infectious diseases and cancer. Several trials and studies have been done to recognize immunomodulatory agents to encounter the infection and enhance host immune mechanisms. Asparagus racemosus, Withania somnifera Moringa oleifera and Ocimum sanctumare medicinal plants having immunomodulatory activity. The present study was carried out by procuring 48 Wistar rats and was randomly divided into six groups consisting of 8 rats in each group. Herbal medicated feed prepared as additive over and above daily nutritional requirement of Wistar rats with addition of Asparagus racemosus, Moringa oleifera, Ocimum sanctum, Withania somnifera @ 2%, 3%, 3%, 3% respectively and combination medicated feed prepared using all these plants in 2%, 3%, 3%, 3% above same concentration ratio. Group I kept as control fed with normal feed and group II to VI fed with 2% Asparagus racemosus, 3% Moringa oleifera, 3% Ocimum sanctum, 3% Withania somnifera and combination feed respectively. HA and DNCB contact sensitivity test were performed to assess the immune response. One rat from each groupss were sacrificed at termination (42^nd) day of experiment. Significant increase in HA titers and DNCB contact sensitivity was observed in all treatment groups and indicating increase in cell medicated immunity and humoral immunity.

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