Author(s):

Brijesh R Humbal, Kamlesh A Sadariya, Jaimin A Prajapati, Shailesh K Bhavsar and Aswin M Thaker

Abstract: The present study was planned to evaluate safety of Syzygium aromaticum oil (clove oil) following oral administration at dose of 50, 100 and 200 mg/kg body weight once daily for 28 days in male and female wistar rats. Body weight and feed consumption of animals were monitored at weekly interval. At the end of experiment, blood sample were collected for the hematological and serum biochemical investigations as well as organs are collected for histopathological examination. No significant difference was observed in body weight and feed consumption of clove oil treated male and female rats as compared to control rats. No significant changes have been observed in Hb, RBCs, PCV, TLCs, MCV, MCH and MCHC in clove oil treated male and female rats at the end of experiment as compared to control rats. No significant change have been observed in serum creatinine, BUN, total bilirubin, AST, ALT, total cholesterol, total protein and albumin in clove oil treated male and female rats as compared to control rats at the end of experiment. Results of the present study suggest that the clove oil was found safe following repeated oral administration @ 50, 100 and 200 mg/kg for 28 days in male and female wistar rats.

Pages: 3027-3032  |  1016 Views  519 Downloads

Download (1428KB)