Author(s):

Dr. Hardy Daniel L and Dr. Ravinrdan Rajan

Abstract: The dopaminergic neuronal death in Substantia nigra leads to Parkinson's disease. Though it is common in western countries, the incidence rises in developing countries. In traditional system, neurodegenerative disorders are treated by Bacopa monnieri. The mechanism underlying its usage in Parkinson’s disease is validated in this study. Five groups of animals were studied for behavioral changes after induction of Parkinson's disease and treatment with methanolic extract of Bacopa monnieri for 60 days. The neuro-behavioral responses and balancing ability were studied. In T-maze test, mild cognitive impairment was observed in Parkinson's disease induced animals which improved with Bacopa treatment, whereas in eight arm-radial maze, the working and reference memory were enriched significantly in Parkinson's disease induced animals treated with BM. The balancing in Rota-rod and narrow beam were improved with Bacopa treatment in Parkinson’s disease induced animals. Thus Bacopa monnieri improves the motor and non-motor symptoms of PD in rat models.

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