Author(s):

Adedokun Oluwasegun, Ogochukwu Ume, Abdulkadir Nasiru, Adebayo Gbolade, Aziba Peter and Gabriel Benjamin

Abstract: Medicinal plants have been useful in treatment of various diseases in man and animals since time immemorial. Annona muricata has been known majorly for cancer management. Ethnopharmacological information revealed the use in treatment of diabetes and oxidative induce lipid peroxidation. Phytochemical screening revealed the presence of the presence of alkaloids, flavonoids, steroids, reducing sugars, and tannins. Total phenolic and flavonoid contents were estimated to be 68.54±0.51 and 55.82±0.85 respectively. Aqueous fraction showed the highest amount of phenolics and flavonoids (46.32±0.76 and 32.81±0.28) relative to chloroform fraction. However, aqueous fraction also showed the highest DPPH scavenging property in a concentration non-dependent manner. Moreover, crude extract and chloroform fraction exhibited the highest (concentration dependent) and lowest (concentration dependent) lipid peroxidation inhibition potentials. Glibenclamide (20 mg/kg), crude extract (500 mg/kg and 1000 mg/kg) and aqueous fraction (250 mg/kg and 500 mg/kg) produced a pronounced decrease in blood glucose in a dose dependent manner over time. No significant difference P≥0.05 was noted among the samples. In conclusion, crude extract of A. muricata exhibited excellent antioxidant, anti-lipid peroxidation using in vitro model as well reduced blood glucose level in albino rats in a manner similar to Glibenclamide (20 mg/kg) P≥0.05. Aqueous fraction was likewise noted to be the most active fraction for the bioassays examined.

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