Author(s):

Subhankari Prasad Chakraborty

Abstract: Human papilloma virus, the major risk factor of cervical cancer, the most common gynecologic malignancy worldwide, accounts for 8.5% deaths per year. Conventional treatments have side effects like nausea, vomiting, loss of appetite and hair, early bruising and bleeding, anemia, renal problems, etc. Hence, there is a need for finding new anti-cancer agents which is to be safe, cost effective, easily available and free from side effects. Medicinal plants have been on the forefront where research on the anti-cancer agent is planned. Keeping this purpose in mind, an attempt has been made in this review to provide evidence based analysis of plant extracts, phytochemical and phytomolecules which exhibit anti-tumorigenic activity or exert cytotoxic effect in human cervical carcinoma cells. This review mainly focuses on several medicinal plants such as Rosmarinus officinalis, Solanum nigrum, Kaffir lime, and Garcinia nujiangensis used in the treatment of cervical cancer and the secondary metabolites derived from different plant sources. Plant molecules such as cisplatin, curcumin, epigallocatechin-3-gallate, EGC, and other catechins that have a wide range of biological properties and the molecular mechanism were reviewed. This review will promote the research on the development of a plant-derived anti-cancer drug with lesser or no side effects and aid in understanding the mechanism of action of several plant-derived molecules. However, efficacy needs to be further investigated in various cervical cancer cell lines and more importantly, in in vivo cervical cancer models for possible use as an alternative and safe anticancer drug.

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