Hematological study and body weight changes of streptozotocin induced diabetic wistar rats treated by hydroethanolic leaf extract of Catharanthus roseus

Dongare Sneha; Somkuwar AP; Dubey SA

Hematological study and body weight changes of streptozotocin induced diabetic wistar rats treated by hydroethanolic leaf extract of Catharanthus roseus

Author(s):

Dongare Sneha, Somkuwar AP and Dubey SA

Abstract:

The present study was conducted in 50Wistar rats, weighing around 150-200 g which was divided into five groups (T_1,T_2,T_3,T₄and T₅). Diabetes was induced by administering Streptozotocin @ 40 mg/kg body weight in groups T₂, T₃, T₄ and T_5.Whereas, T₁ group was maintained as normal control. The group T₂ was maintained as diabetic control. The group T₃ was treated with metformin (standard antidiabetic drug) at 100 mg/kg bd wt. Groups T₄ and T₅were treated with hydroethanolic leaf extract of C. roseus @ 200 and 400 mg/kg b. wt. respectively. In the experiment, blood was collected on 0^th, 14^th and 28^th day for hematological studies.

Hydroethanolic leaf extract of C. roseus caused significant decrease in the elevated blood glucose levels of the rats from these groups on 14^th and 28^th day of the experiment.

Heamatological parameters levels altered due to the Streptozotocin induced diabetes were observed to be normal range by the treatment with C. roseus leaf extract @ 400 mg/ kg followed by the dose rate of 200 mg/ kg.

In treated groups it has been observed that the average weight were increased up to 28^th day of treatment, however, this increased was less as compared to weights of normal group of rats at the same time in all the treated groups (T₃, T₄ and T₅) weights of rats were significantly increased as compared to diabetic group (T₂).

The present study is concluded that the Catharanthus roseus reduce the blood glucose level, improved body weight and elevated Hb and PCV to the rats.

Pages: 2933-2937 | 719 Views 207 Downloads

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Journal of Pharmacognosy and Phytochemistry

How to cite this article:

Dongare Sneha, Somkuwar AP and Dubey SA. Hematological study and body weight changes of streptozotocin induced diabetic wistar rats treated by hydroethanolic leaf extract of Catharanthus roseus. J Pharmacogn Phytochem 2019;8(3):2933-2937.

Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

Vol. 8, Issue 3 (2019)

Hematological study and body weight changes of streptozotocin induced diabetic wistar rats treated by hydroethanolic leaf extract of Catharanthus roseus

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