Journal of Pharmacognosy and Phytochemistry
Vol. 8, Issue 3 (2019)
Assessment of anti-arthritic, antiâ€inflammatory and antioxidant activity of Melia dubia
Author(s):
HN Krishna Kumar and Jyoti Bala Chauha
Abstract:
The present investigation deals with the phytochemical screening, anti-arthritic, antiâ€inflammatory
and antioxidant potentials of ethanolic fruit extract of
Melia dubia. Phytochemical screening studies of the extract showed the presence of flavonoids, steroids, saponins, alkaloids, glycosides and tannins. Evaluation of total phenolic contents revealed that the extract contains 142.8 mg/g of phenolic compounds. The antioxidant activity of the extract was evaluated through DPPH assay and reducing power assay. The free radical scavenging activity of the extract was confirmed in a DPPH assay. The extract showed the stronger radical scavenging effect with IC
50 value of 55.4μg /ml. The reducing power of the extract observed was concentration dependent which is comparable with the standard antioxidant butylated hydroxyanisole (BHA). The plant exhibited good anti-arthritic activity in a dose dependent manner. The extract showed highest inhibitory activity of 81.2% with an IC
50 value of 58.2 μg/ml. Likewise, the fruit extract of
Melia dubia showed strong antiâ€inflammatory activity in a concentration dependent manner with an IC
50 value of 52.6 μg/ml.
Pages: 2579-2582 | 1206 Views 483 Downloads
HN Krishna Kumar and Jyoti Bala Chauha. Assessment of anti-arthritic, antiâ€inflammatory and antioxidant activity of Melia dubia. J Pharmacogn Phytochem 2019;8(3):2579-2582.