Author(s):

Lekshmi VS and G Muraleedhara Kurup

Abstract: The scientific validation of the bioactivities of sulfated polysaccharides (SPSs) from the edible marine algae glorifies the traditional aspects of their medicinal properties. The SPSs are the major structural ingredient of the algal cell wall composition. The aim of the present study is to evaluate the combined anticoagulant efficacy of SPSs purified from the edible marine algae Padina tetrastromatica and Ulva fasciata. After in vitro analysis, the results were confirmed by in vivo studies in SD rats induced with venous thrombosis. During the study, both compounds were found to have heparin-like anticoagulant properties. That is, these heparinoid-active compounds exert antithrombotic activity through the modulation of the intrinsic coagulation pathway. The overall results established that the combined effects of algal sulfated polysaccharides are more beneficial than the individual effects and they also showed excellent antiplatelet aggregation properties. In short, the study enlightened the pharmacological potential of the edible algae and their novel compounds sulfated polysaccharides.

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