Author(s):

Lisha V, Preethy John, Sujith S and Usha PTA

Abstract: Hyperlipidemia causes overproduction of oxygen free radicals which leads to oxidative stress. Lipid lowering drugs for treating hyperlipidemia is associated with many adverse effects. So, bioactive components with hypolipidemic and free radical-scavenging activities have received much attention as potential, nontoxic alternative. The present study was aimed to evaluate the ameliorative effect of Averrhoa bilimbi fruit powder in oxidative stress induced by high fat fed diet in liver as well as kidney. Forty eight rats were divided into six groups of eight animals each. Hyperlipidemia was induced by giving HFD for 15 days for all groups except normal control. Rats were fed with A. bilimbi fruit powder (125, 250 and 500 mg/kg body weight) and with rosuvastatin (10mg/kg body weight) orally from 16^th day along with HFD for 30 days. The animals were sacrificed on day 45 and the liver as well as kidney tissues were dissected out for the assessment of antioxidant status. Antioxidant enzymes like SOD, GSH were found to be increased along with a decrease in LPO after the treatment with A. bilimbi. The result indicated the potential of A. bilimbi fruit powder in lowering the high fat diet induced oxidative stress in rat liver and kidney.

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