Author(s):

Dhara R Bhatt, Khushboo D Jethva and Maitreyi N Zaveri

Abstract: The global burden of breast cancer is increasing with alarming rates. The current research trend in the cancer is focused towards finding the safe and effective therapy from the traditionally used medicinal plants. Eulophia nuda is one such terrestrial orchid which has been traditionally used for the treatment of tumours. In the present study, the alcoholic, hydro alcoholic and aqueous extracts of E. nuda tubers were studied in-vitro for their cytotoxic activity using two different models for cytotoxicity, brine shrimp lethality assay and MTT assay. The MTT assay was performed on the breast carcinoma cell line MCF7 and on the non-cancerous Vero cell line. The results suggested that the alcoholic extract of E. nuda showed the most significant cytotoxicity, 80.77% on the MCF7 cell line at the concentration of 1000 μg/ml. The extract did not show any cytotoxicity on the Vero cells, and hence it could be considered safe to the normal cells. Further in-vitro and in-vivo studies are necessary to establish the use of E. nuda for the treatment and management of the breast cancer.

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