Author(s):

Nagarajan D and Pandian R

Abstract: In the present study, anti-cancer activity of the endophytic fungi isolated from two medicinal plants, Enicostemmaaxillare and Ormocarpumcochinchinense was examined. Four endophytic fungi were isolated and identified based on morphological characteristics and microscopic structures. The extracts were screened for cytotoxicity against MCF-7 cell lines by MTT (3-(4, 5-Dimethylthiazol-2-yl)-2,5Diphenyltetrazolium Bromide) assay. The fungus Phialophora isolated from Enicostemmaaxillare showed the highest cytotoxicity. Further, the fungal extract EAR2 was purified using preparative TLC. GC-MS (Gas Chromatography-Mass Spectrometry) analysis was carried out to identify the compounds present in the purified extract. Isopropyl myristate was identified as the major compound.

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