Author(s):

Sandeep Dewal, Rucha Lakhne and RS Gupta

Abstract: This study was conducted aiming to evaluate the chemical composition of the plant by GC-MS analysis and investigate its antifertility activity. The contraceptive activity was studied in male rats by oral administration of methanolic extract of Cassia siamea (stem bark) of two doses (50 and 100 mg/kg b. wt.) over a period of 60 days. After sacrificing the animal blood was collected for hormonal analysis and reproductive organs are dissected for histopathological examination. There was no significant changes were observed in the body weight whereas the weight of the reproductive organs reduced significantly (p<0.01). Sperm motility and sperm density (p<0.01) in epididymis decreased significantly that affected the process of spermatogenesis. The levels of androgens and gonadotropins (FSH, LH and testosterone) decreased significantly (p<0.01) interfering with the spermatogenic activity. The levels of glycogen, sialic acid and protein (p<0.01) also reduced significantly when administrated with the drug. The histopathological findings supported the suppression of fertility capacity in male rats. These results suggested that the Cassia siamea (stem bark) methanolic extract possess antifertility activity by suppressing the levels of hormones and other biochemical involved in markers spermatogenesis.

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