Author(s):

Dr. Vikas jaiswal, Dr. Aarti Bhatele, Dr. Nilesh kumar Pagrut and Dr. Harshit verma

Abstract: The present study has been carried out to study effect of lead, cadmium and its mixture on blood and biochemical parameters in Wistar rats. Fourty eight colony bred albino Wistar rats of both sexes, were divided uniformly into four different groups. The group I treated with only deionised water and served as negative control while, group II, III and IV were orally gavaged with cadmium chloride @ 100PPM; lead acetate @ 500PPM; and mixture of cadmium chloride @ 100 PPM & lead acetate @ 500 PPM respectively for 28 days. All the three treatment groups showed anemia. Though leucocytopaenia has been observed in all the treatment groups with highest effect in group IV, differential leukocyte count (DLC) did not differ significantly in any of the group. There was increase in Alkaline phosphatase (AKP), Gammaglutamyl transferase (GGT), Creatinine, while decrease in Total protein (TP) and Albumin suggesting hepatic and renal damage caused by these metals.

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