Author(s):

Orji Blessing O and Obi Frederick O

Abstract: This study evaluated the effects of concurrent administration of paracetamol and aqueous extract of Hibiscus sabdariffa Linn calyx on paracetamol-associated hepatotoxicity in mice under sub-chronic and chronic conditions. It comprised of four groups of five mice each to reflect control, extract only, paracetamol only and concurrent administration of paracetamol and extract. Paracetamol (500mg/kg body weight) and Hibiscus sabdariffa Linn calyx extract (250mg/kg body weight) were administered orally to experimental mice. Paracetamol toxicity was evidenced by significant increases (P≤.05) in ALT, AST, ALP and GGT activities, total cholesterol and bilirubin levels, and decreased serum total protein and albumin levels. Also found were significant decreases (P≤.05) in catalase and SOD activities, GSH level, and increase (P≤.05) in MDA level, relative to control. Concurrent administration of paracetamol and extract proved effective in ameliorating paracetamol-associated liver injury in mice particularly at the sub-chronic phase where the values of many of the parameters returned to control.

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