Author(s):

Vawazola Nsimaketo Victor Héritier, Dani Nzizidi Arthur, Malumba Mukaya Augustin, Ngombe Kabamba Nadège, Kizungu Vumilia Roger, Sumbu Zola Lezi Pierre Eric et and Masimango Ndyanabo Jude-Thaddée

Abstract: This work aimed to highlight antibacterial and antiplasmodial potentials of Zingiber officinalis and Monodora myristica essential oils. The extraction yields in essential oils were 1.28±0.05% for Z. officinalis rhizome and 1.52±0.14% for M. myristica seeds. Diameter of the inhibition zone formed as a result of Z. officinalis oil is 39.17±1.44 mm, 37.00±4.33 mm, 36.17±6.64 mm and 20.67±2.26 mm respectively for Salmonella sp, Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus strains; for M. myristica oil, 11.00±1.00 mm, 7.83±2.75 mm, 7.67±1.53 mm and 6.00±0.00 mm; and for eugenol used as control, 18.5±1.32 mm, 18.83±1.04 mm, 18.50±0.5 mm and 20.17±3.25 mm. The MIC of Z. officinalis oil is 0.25% on Salmonella sp, Klebsiella pneumoniae and Staphylococcus aureus strains and 0.5% on Pseudomonas aeruginosa strain; the MIC of M. myristica oil is 0.1% on Salmonella sp and Staphylococcus aureus strains, 0.25% on Pseudomonas aeruginosa strain and 0.5% on Klebsiella pneumoniae strain and it is 0.05% for eugenol on all bacterial strains. The MBC of Z. officinalis oil is 0.5% on Staphylococcus aureus strain, 1% on Salmonella sp and Klebsiella pneumoniae strains and higher than 3.5% on Pseudomonas aeruginosa strain; the MBC of M. myristica oil is higher than 3.5% on all strains; for eugenol, the MBC is 0.1% on Staphylococcus aureus strain and 0.5% on Salmonella sp, Pseudomonas aeruginosa and Klebsiella pneumoniae strains. Z. officinalis oil has a bactericide action on Salmonella sp, Klebsiella pneumoniae and Staphylococcus aureus strains and a bacteriostatic action on Pseudomonas aeruginosa strain; M. myristica oil has a bacteriostatic action on all bacterial strains. Z. officinalis oil make total inhibit completely trophozoites up to the concentration less than 6.25μg.mL^-1 while M. myristica oil make total inhibit completely trophozoites up to the concentration of 12.5μg.mL^-1 and below this concentration, inhibition become partial.

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